Pro-Resolving Mediators to Support a Healthy Immune Response*
Expanding on the substantial health benefits of EPA and DHA Omega-3 fatty acids, PRM Careis an enhanced marine lipid concentrate with enriched levels of pre-resolving mediators(PRMs) that may offer superior efficacy over standard Omega-3 ingredients. PRM’s are metabolites of Omega-3s that are further converted into active compounds that widely mediate many of Omega-3s known biological actions and functions. Naturally found at low levels in marine lipids, 3Care Therapeutics uses proprietary fractionation methods to create high PRM enriched Omega-3 ingredients.
PRMs are metabolites of EPA, DHA and DPA. The most abundant metabolites being 14-HDHA, 17-HDHA and 18-HEPE. These metabolites and other similar compounds are further metabolized to form various classes of Specialized Pro Resolving Mediators(SPMs), such as lipoxins, resolvins, meresins, and protectins. SPMs are reduced lipid signaling agents that are known to promote the resolution of inflammation and to encourage the healing process via interaction with various types of immune cells. Elevated SPM requirements due to injury, trauma, or chronic inflammation, may not be adequately met based upon omega-3 status, biochemical individuality, or host lifestyle issues. Including PRM metabolites along with Omega-3 fatty acids is emerging as a promising modality to support the healthy formation of SPMs required for homeostasis and optimal immune activity.
Emerging research shows that PRMs and their metabolite SPMs facilitate various cellular and biological functions traditionally attributed to Omega-3s. Studies indicate these compounds may have a vast range of potential benefits including cardiovascular, neurological, immunological, and cognitive health.
Proposed health benefits*:
- Improves Omega-3 status (1)
- Supports a healthy blood lipid profile (2)
- Supports unique lipid mediator profiles (3)
- May support a healthy heart (4)
- Supports a healthy blood lipid profile
- Supports unique lipid mediator profiles
- Promotes balanced immune activity and homeostasis (5)
Serhan CN, Chiang N, Dalli J (2015). "The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution". Seminars in Immunology. 27 (3): 200–15. doi:10.1016/j.smim.2015.03.004. PMC 4515371. PMID 2585721